|1 tablet contains:||% RDA*|
|Corresponding to 600 mg of L-tryptophan|
* RDA: Recommended Daily Allowance.
** RDA: Not established
1 tablet daily, unless otherwise adwised; half an hour before bedtime. Sublingual tablet - do not swallow.
Do not exceed the recommended daily dosage.
Not suitable for pregnant and breastfeeding women.
Excessive consumption may have a laxative effect.
A healthy lifestyle and a varied balanced diet are important for maintaining good health.
Suitable for vegetarians.
natural tomato extract,
flavor enhancer: glycine,
vitamin B3: nicotinic acid,
firming agent: polyvinylpyrrolidon,
anti-caking agent: magnesium salts of fatty acids,
flavor enhancer: raspberry extract, melatonin.
Dark, dry and at room temperature.
Keep out of reach of young children.
What is Bio-Melatonin Complex?
Bio-Melatonin Complex is a nutritional supplement containing sublingual tablets with 290 µg of the active substance melatonin and also 10 mg of the vitamin niacin which is a precursor to melatonin.
Oral administration of melatonin in a tablet form is poorly absorbed with about 15% reaching the systemic circulation. The bioavailability increases when melatonin is administered in the form of a lozenge where it is absorbed through the oral mucosa (sublingual absorption). Sublingual administration of melatonin bypasses the first passage metabolism in the liver, that reduces bioavailability, and has been shown to increase the maximal blood concentration 38% relative to oral intake in a tablet form.
Also note that Bio-Melatonin Complex contains niacin. For the production of niacin, the body requires tryptophan, which the body also uses to synthesize melatonin. Adding 10 mg of niacin to the product spares 600 mg of tryptophan. Take Bio-Melatonin Complex half an hour before bedtime. The effect of Bio-Melatonin Complex may be optimized by taking it at the same time every night.
What is melatonin?
Melatonin is a natural component found in a long line of living organisms. We find a high amounts in the fruit of bananas and in plants of the rice family. In most animals including man, melatonin functions as a key substance involved in seasonal and diurnal rythms. In humans melatonin is secreted from the pineal gland in the brain and controlled by a region of the hypothalamus. The synthesis and release of melatonin is stimulated by darkness and peaks between 2am and 4am and is inhibited by light.
If you get up during the night and turn the light on, your body's melatonin production will immediately stop and only reach maximum production again after some hours of darkness. However, not all frequencies in the light spectrum attenuates the production of melatonin. It is only light in the blue end of the visible light spectrum, which attenuates the production of melatonin, but this type of light is present in many artificial sources of light.
In humans the brain's production of melatonin is at its highest from 3-5 years of age until adulthood. Hereafter production gradually declines the rest of our life.
Where can melatonin be found?
- Sweet corn
What is nicotinic acid?
Nicotinic acid is the name given to vitamin B3. It is sometimes also called niacin. This vitamin was first isolated from tobacco leaves, but it is not identical to the substance nicotine.
The vitamin is involved in many important bodily functions, of which include that it contributes to the normal function of the nervous system including the brain and our psychological function.
In the body the amino acid tryptophan contributes in the production of nicotinic acid if the intake is low and also to the neurotransmitter serotonin. Serotonin can enzymatically be converted back and forth to melatonin.
The circadian rythm
In the brain, we have a sort of a biological clock that controls our circadian rhythm. This circadian rhythm is the physical, mental and behavioral changes that follows a cycle close to 24 hours. The rythm primarily responds to light and darkness.
Our biological clock maintains an individual circadian rhythm which are not totally equal to 24 hours, it might be a little shorter or a little longer, but is adapted to a 24 hour daily rhythm by means of the the daylight, that hits the eye.
The European Food Safety Authority (EFSA) has evaluated the evidence behind niacin and has acknowledged the following claims:
- Contributes to normal functioning of the nervous system
- Contributes to normal psychological function
- Contributes to normal energy-yielding metabolism
- Contributes to the reduction of tiredness and fatigue