Bio-Vitamin D3 (D-Pearls)
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|1 capsule contains||% RDA*|
|Vitamin D3 (Cholecalciferol)||125 µg||2500%|
*RDA= Recommended Daily Allowance
1 capsule per day or as directed by a health professional. Preferebly with a meal.
Do not exceed the recommended amount.
Pregnant and lactating women and those on medication should seek professional advice prior to taking supplements.
Dietary supplements should not be used as a substitute for a varied diet or healthy lifestyle.
Bulking agent: Olive oil
Capsule shell: Bovine gelatin
Humectant: Glycerol, purified water
Vitamin D3 (Cholecalciferol)
Colour: Iron oxide
Store at room temperature.
Keep out of reach of children.
What is Bio-Vitamin D3, 125 µg?
Bio-Vitamin D3 (D-Pearls) are small, soft gelatin capsules with 5000 IU (125 µg) vitamin D3 in each capsule designed for high need for vitamin D. The vitamin D is dissolved in cold-pressed olive oil to improve absorption in the digestive system as vitamin-D is a fat-soluble vitamin. Their size makes them easy to swallow, but they can also be chewed. Research has shown that D-Pearls have a high absorption in the body.
Safety and quality
At Pharma Nord's factory in Vojens, Denmark, both medicines and dietary supplements are produced, which makes it possible to carry out the same control with dietary supplements as is already done with medicines. Both dietary supplements and medicines are examined on the basis of a carefully determined plan - which ensures that the products contain what the specification says. This gives consumers an assurance that each D-Pearl contains the amount of vitamin D listed.
The small gelatin capsules can naturally vary in their firmness in step with fluctuations in air temperature and humidity.
It has absolutely no bearing on the quality and effect of the capsules as we have tested this in our climate cabinets.
D-Pearls has been on the European market since 2007.
Pharma Nord's D-Pearls have been tested by researchers at the University of Oslo, who gave athletes different doses of vitamin D from D-Pearls or matching inactive placebo capsules. The study showed that the vitamin D from D-Pearls in both high and low dosage was well absorbed by the participants, whereas the athletes who had received placebo had an unchanged content of vitamin D in the blood.
The illustration shows the difference in vitamin D in the blood during 4 weeks in the group receiving 76 mcg (3040 IU) of vitamin D daily and in the group receiving placebo capsules.
Source: Baumann ACK. Effekt av vitamin D-tilskudd på 25(OH)D status. University of Oslo, July 2013.
What is vitamin D?
Vitamin D is a fat-soluble vitamin. This implies that the vitamin need some fat in order to be absorbed in the intestine. Like other vitamins, vitamin D is essential. There are several kinds of vitamin-D, but the two most important forms are D2 (ergocalciferol) and D3 (cholecalciferol).
Vitamin D2 Is only available from the diet. It is produced by certain fungi and plants when they are exposed to ultraviolet light.
Science used to believe that both forms of vitamin D were equally effective in the body. However, depending on the measuring method used, vitamin D3 is 56-87 per cent more effective than vitamin D2 when it comes to raising blood levels of vitamin D. Moreover, D3 is stored in fat tissue more than three times as effectively as D2. *
* Heaney RP, et al. Vitamin D3 Is More Potent Than Vitamin D2 in Humans. J Clin Endocrinol Metab 2010.
Children and nursing home residents need more vitamin D than adults.
Vitamin D has an array of important functions in the body. For instance, vitamin D is:
- Important for normal cell division
- Helping to maintain normal bones and teeth
- Contributing to a normal absorption and utilization of calcium and phosphorus
- Playing a role in the body's immune system and muscle function
Sources of Vitamin D
There are two primary sources of vitamin D: Sunlight and Diet.
Vitamin D from the Sun
We form a precursor to vitamin D3 in the skin based on cholesterol when we get enough sunlight or equivalent UV radiation. This precursor must subsequently be converted (hydroxylated) in the liver and kidneys, respectively, to become active vitamin D.
Vitamin D from sunlight is an effective vitamin D source but is only produced when the sun is high in the sky. In large parts of Europe, this only happens during the summer period, and therefore we can only produce sufficient levels of the vitamin this time of year.
Rule of thumb
To form vitamin D from sunlight, the UV index must be at least 3 or higher. The UV index is used as a measure of the intensity of the Sun's ultraviolet radiation. If you are in doubt about whether you can form vitamin D from the Sun, look at your shadow. If the length of your shadow has the same or shorter length than your height, then you can form vitamin D. If, on the other hand, the shade is longer than the height, vitamin D is not formed.
Vitamin D from the diet
Vitamin D is found only in larger amounts in oily fish, such as salmon, herring and mackerel. Additionally occurring vitamin D are found in limited quantities in meat, dairy products and eggs. In the plant kingdom vitamin D is available only in small amounts in certain fungi. In our diet some of the best sources of vitamin D are:
There is some loss of vitamin D from the diet when heated.
The need for vitamin D
- Individuals with dark pigmentation as they require 5 to 10 times more exposure to sunlight to generate same amounts of vitamin D3 as individuals with little or no pigmentation
- Anyone who, regardless of their age, are at increased risk for osteoporosis
- People who do not spend time outdoors in the daytime or generally avoid sunlight
- Adults who wear fully covering clothes in the summer time
- Nursing home residents
- People older than 70 years. An older skin is less able to generate vitamin D3 from sunlight
Vegans and vegetarians are advised to adhere to the official guidelines for sun exposure and possibly take a supplement of vitamin D during the winter period.
Blood levels of vitamin D can be determined by a blood test that measures the unit 25-hydroxyvitamin D (25-(OH)D) and is expressed in nmol/l. Vitamin D status is graduated in the following way:
|Unit: nmol/l||Unit: ng/ml ~ µg/L|
> = greater than
< = less than
Vitamin D Conversion
- 1 nmol/l = 0,4 ng/ml ~ 0,4 µg/L
- 75 µg = 3000 IU (international units)
Measurement of vitamin D
The safest way to know one's vitamin D status is by means of a blood test. However, for normal, healthy individuals there is no immediate need to measure blood levels of vitamin D. For certain groups, however, it is advisable to gauge their vitamin D status.
For instance, people with a lifestyle that gives reason to believe that they could benefit from checking their status. Besides the obvious factors that limit vitamin D such as lack of sunlight and poor diet, there are more subtle causes such as the fact that some types of medicine may affect the body’s vitamin D absorption, thereby increasing the need for this particular nutrient.
Vitamin D and the normal aging process
Although the aging process affects us differently depending on our genome and lifestyle, everyone will find that, over time, the body becomes worn out and functions less efficiently. This phenomenon is part of the normal aging process and can also have an effect on the amount of vitamin D we need.
Most of the body's cells are equipped with vitamin D receptors, which are small structures on the cells’ surface that are activated by active vitamin D3. These receptors on the different cells is also the explanation for the many different effects of vitamin D in the body.
The immune system
It became clear that vitamin D contributes to the normal functioning of the immune system when it was discovered that various white blood cells such as macrophages and dendritic cells as well as T and B lymphocytes are equipped with vitamin D receptors. Vitamin D is necessary for these immune cells to perform their functions. For example, it has been shown that active vitamin D activates genes in the cell nucleus; these genes encode peptides that inhibit viruses, bacteria and fungi.
Our immune system reaches peak efficiency in the teenage years. Even in healthy elderly people, the immune system has become more vulnerable to new infections that it has not encountered before. The elderly, for example, have fewer white blood cells in the blood, and the degree of inflammation in the body is higher than in younger people. Older people should pay special attention to getting enough vitamin D.
Our bone mass peaks at the age of 20 - 30 years. After this, the bone tissue slowly becomes lighter and more porous. Vitamin D is necessary for normal bones and teeth because vitamin D helps us to maintain a normal content of calcium in the blood, and vitamin D is necessary for bones and teeth to absorb calcium.
From the age of 40, there is a gradual loss of bone mass on the order of 0.5% annually for men and about twice as much for women.
Our muscles also need vitamin D to function normally. The ability of muscles to contract is dependent on calcium ions. As previously mentioned, vitamin D regulates the blood's content of calcium and in this way also regulates muscle function.
As we get older, the number of vitamin D receptors in muscle tissue decreases. This results in a gradual loss of muscle mass and muscle strength. The heart muscle, on the other hand, is not significantly affected by this.
Skin and mucous membranes
It is known that the body produces a precursor to vitamin D in the skin when exposed to sunlight of a certain intensity, i.e. a wavelength between 290 - 315 nm. Factors that prevent or reduce the production of vitamin D from sunlight are severe air pollution, clothing, dark skin, use of sunscreen, obesity, the sun’s being too low in the sky, and old age.
With increasing age, the amount of collagen and elastin decreases, making the skin flabbier and more wrinkled. The skin becomes less efficient at producing vitamin D from sunlight, and the digestive tract becomes less efficient at absorbing vitamin D.
The European Food Safety Authority (EFSA) has evaluated the evidence behind vitamin D and has acknowledged the following claims:
- Contributes to a normal absorption/utilization of calcium and phosphorus
- Contributes to normal blood calcium levels
- Contributes to the maintenance of normal bones
- Contributes to the maintenance of normal muscle function
- Contributes to the maintenance of normal teeth
- Contributes to normal function of the immune system
- Has a role in the cell division process
- For men and woman 60 years and older: Vitamin D helps to reduce the risk of falling associated with postural instability and muscle weakness. Falling is a risk factor for bone fractures among men and woman 60 years of age and older. (Art 14a)
Bio-Magnesium: Magnesium has several sites in common with vitamin D although the two ingredients cannot replace each other: For example, both contribute to the maintenance of normal bones and teeth, a normal muscle function. Also they both play a role in cell division.