Effective precursor to NAD+

Bio-NAD+ Booster consists of white tablets, each containing 250 mg of niacin divided into nicotinamide and nicotinic acid. The recommended dosage for Bio-NAD+ Booster is two to three tablets daily, divided over the day. The product's formulation has been developed by Pharma Nord and is based on scientific research. The active substances in the tablets are released slowly, which provides optimal absorption and utilization in the body.

Why a booster?
In 2020, researchers at the University of Helsinki published the results of a clinical trial, which showed that a combination of nicotinamide and nicotinic acid in a special slow-release tablet increased NAD+ levels in the blood up to eight times over a few months.

This research is the basis for Bio-NAD+ Booster. Supplementation of NAD+ is therefore unnecessary. This is because supplementing NAD+ or NADH in the blood will not benefit the cells significantly. Instead, the body's cells must produce it themselves. Therefore, an NAD booster is preferable, as it contains the precursors so that the cells can form it themselves.

There are a number of different substances that act as precursors to NAD in the body through a variety of biological processes. Examples of these precursors include nicotinic acid, nicotinamide, nicotinamide riboside (NR), and nicotinamide mononucleotide.

NAD (nicotinamide adenine dinucleotide) is a coenzyme that is central to metabolism. NAD, which is found in all living cells, is called a dinucleotide because it consists of two nucleotides linked by their phosphate groups. One nucleotide contains an adenine nucleobase and the other contains nicotinamide. NAD exists in two forms in the body: NAD+, which is the oxidized form, and NADH, which is the reduced form.

NAD is classified as a coenzyme, i.e. a substance that enables biochemical reactions to take place in the body.

NAD in both oxidized and reduced forms plays an important role as the tiny power plants of cells (the mitochondria) convert calories from food into energy. The citric acid cycle and the electron transport chain are key steps in the energy conversion of cells. It is through these processes that we can form the molecule ATP, which is our "energy currency", which is used in the body's energy-requiring processes.

Niacin is converted to NAD
Niacin (in the form of nicotinamide and nicotinic acid) belongs to the group of B vitamins that are converted to NAD in the body. NAD is produced in the body via different synthesis pathways, such as from the amino acid tryptophan (de novo synthesis) or from niacin (Preiss-Handler synthesis). The body's natural NAD production decreases as we age because these signaling pathways become less efficient.

Because niacin, like the other B vitamins, is water-soluble, it can be absorbed into the bloodstream fairly quickly from the gut. However, water-soluble nutrients can be lost by diuretics such as caffeine, alcohol, and drugs because they cause the body to lose water.

Niacin in a slow-release formula allows the compounds to be absorbed slowly into the bloodstream. This allows for a steady release and prevents large losses.

The European Food Safety Authority (EFSA) has evaluated the scientific evidence regarding the positive health effects of niacin. The following health claims have been approved:

Niacin

Contributes to a normal functioning nervous system

• Contributes to a normal energy-yielding metabolism
• Contributes to normal psychological function
• Contributes to the maintenance of normal skin and mucous membranes
• Helps reduce tiredness and fatigue