Leading NADH formula

Nicotinic acid from food and supplements is converted in the body into its main metabolically active form, nicotinamide adenine dinucleotide (NAD).

NAD has two main forms: NAD+ (known as the oxidized state) and NADH (known as the reduced state). NAD in either form plays a major role in the citric acid cycle and the electron transport chain that are key steps in respiration that occur in the mitochondria, also known as the cellular powerhouses. It is through this process that the body generates the energy it needs to function. The energy is stored in molecular form as ATP (adenosine triphosphate).

NAD+ is also used by specialist proteins in the cells known as sirtuins which, in turn, play an important role in various biochemical processes and cell functions.

NADH is the energy-rich form that supplies coenzyme Q10 with electrons.

NAD is produced in the body in different ways. It can be synthesized either from l-tryptophan (via the de novo synthesis pathway) or from vitamin B3 (nicotinamide or nicotinic acid, via the Preiss handler pathway).

Our natural NAD production declines with age because the two synthesis pathways become less efficient.

The European Food Safety Authority (EFSA) has evaluated the evidence behind niacin and has acknowledged the following claims:

•     Contributes to normal functioning of the nervous system
•     Contributes to normal psychlogical function
•     Contributes to normal energy-yielding metabolism
•     Contributes to the reduction of tiredness and fatigue