Patented organic bioavailable selenium yeast 200 µg
- The original selenium yeast that is developed and manufactured in Denmark
- Each tablet contains 200 µg of the well-documented and patented SelenoPrecise selenium yeast
- For a well-functioning immune system
- Documented stable absorption (89%) with each batch
- Used in the groundbreaking KiSel-10 study (International Journal of Cardiology, 2013)
- Manufactured under Danish pharmaceutical control
- Scientifically documented
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|1 tablet contains||% RDA *|
* RDA= Recommended Daily Allowance.
1 tablet daily, unless otherwise advised.
Preferably during/after a meal.
Do not exceed the recommended daily dosage.
Dietary supplements should not replace a varied diet.
A healthy lifestyle and a varied balanced diet are important for maintaining good health.
Suitable for vegetarians.
Selenium yeast (SelenoPrecise*), bulking agent: microcrystalline cellulose, firming agents: dicalcium phosphate, silicon dioxide, anti-caking agent: magnesium salts of fatty acids. glazing agents: hydroxypropyl methylcellulose.
*EP Patent No. 1 478 732 B1
Dark, dry and at room temperature. Keep out of direct sunlight.
Keep out of reach of young children.
What is Bio-Seleen Forte (SelenoPrecise 200 µg)?
Bio-Seleen Forte (SelenoPrecise 200 µg) is the high-dosed version of Pharma Nord's patented and standardized selenium yeast. The small, round white tablets each containing 200 micrograms of selenium from Pharma Nord's patented, standardized selenium yeast. Besides selenomethionine SelenoPrecise contains more than 20 other organic selenium compounds. SelenoPrecise has documentation for its very high level of bio-availability and stable quality:
- 15 laboratories in 12 different countries have measured the content of L-methionine selenium in SelenoPrecise to be high and stable
- 89% of the selenium content is absorbed in the body
Why so many different selenium compounds?
SelenoPrecise contains many different selenium compounds because each type of selenium has different functions in the human body. By supplying a wide spectrum of selenium compounds it is possible to emulate the natural variety of selenium types found in selenium rich food. This, scientists believe, has the best effect on our health.
Pharma Nord's selenium yeast as an Active Pharmaceutical Ingredient
Pharma Nord is currently the only manufacturer in the world that is approved to manufacture organic pharmaceutical-grade selenium yeast. This unique, patented medical raw material is used in Denmark under the name SelenoPrecise and is indicated for preventing and treating selenium deficiency. All Pharma Nord's dietary supplements with selenium contain SelenoPrecise.
SelenoPrecise API (Active Pharmaceutical Ingredient)
SelenoPrecise includes many different selenium species, each of which has been shown to have different functions in our body. By supplying the body with a wide range of selenium species, it is possible to emulate the natural selenium variation found in a versatile diet. This means that the different selenium compounds can follow different biological pathways in the body and remain in the blood for varying periods of time. This is believed to have the greatest health benefit. Among the advantages seen with organically bound selenium species from selenium yeast are higher absorption and bioavailability than what you see with inorganic selenium forms and synthetically produced selenomethionine.
The challenge: homogeneity
It is a challenging task to produce a homogeneous selenium yeast, which means that the selenium content in tablets taken from any production batch is always the same. If the deviations fall outside a very tight limit, the selenium raw material does not qualify for medical purposes. The tolerated deviation in declared and actual selenium content is extremely small. Also, the content of different selenium species from batch to batch must be within very narrow margins. It all makes sense because it is only fair that consumers expect the exact same effect with every tablet they take. The goes for scientists who use SelenoPrecise for research purposes.
Pharma Nord's selenium yeast contains more than 20 different selenium species, the content of organic selenomethionine is stable at 67%, and the proportion of inorganic selenium never exceeds 1% of the total selenium content.
Selenium compounds in SelenoPrecise
In analytical studies of SelenoPrecise selenium yeast, the following selenium compounds have been identified:
Selenomethionine, selenomethionine selenium oxide (SeOMet), selenocysteine-se-methylselenocysteine, trimethylselenonium, selenomethylselenocysteine, selenomethylselenomethionine, gamma-glutamyl-se-methylselenocysteine, selenocysteine and polypeptides or low-molecular-celled polypeptides. In particular, the important selenocysteine-se-methylselenocysteine compounds that are found in high concentrations in garlic and are considered to have a special protective effect, are optimized in SelenoPrecise compared to other selenium preparations.
Production of selenium yeast
Pharma Nord's selenium yeast is produced by means of fermentation. Live yeast cells (non-GMO) are "fed" ammonia as well as glucose, vitamins, minerals and inorganic selenium (pharmaceutical-grade). The yeast cells incorporate and integrate the selenium into their cell walls and become part of the proteins in the yeast cells. That way, the inorganic selenium is converted into natural, organic selenium yeast.
The selenium yeast is then pasteurized, a process that causes the yeast cells to die. The selenium-containing yeast cells are then centrifuged, washed, frozen, pulverized, spray-dried, and compressed into tablets.
There are distinct advantages associated with taking API selenium yeast compared with other selenium forms.
⦁ It is organic. The selenium content stays longer in the body than inorganic selenium and it also remains active longer before it is washed out
⦁ It contains more than 20 different selenium compounds found in nature in a selenium-rich diet.
⦁ It has a very small variation in the amount of its various selenium compounds.
⦁ You get the same effect from tablet to tablet as with medical preparations.
⦁ It has given the best results in scientific studies.
* EP Patent No. 1 478 732 B1.
What is selenium?
Selenium is an essential trace element that supports an array of selenoproteins and selenium-dependent enzymes that are important for human health and well-being. One of these enzymes is glutathione peroxidase (GSH-Px), which has several important functions in the body. In addition, selenium supports a normal thyroid function. The thyroid function is important for keeping the metabolic rate in balance. Furthermore, selenium supports biological processes such as:
⦁ a normal immune system
⦁ production of normal sperm cells
⦁ cell protection
⦁ the maintenance of normal hair and nails
Most of the selenium in the body is found in two forms:
Selenomethionine (that is embedded in different proteins instead of methionine) and selenocysteine.
We only get selenomethionine from the diet because the body is unable to synthesize it. However, the body is able to convert selenomethionine into selenocysteine, which we are also able to get from the diet in the form of se-methylselenocysteine.
In situations where we get too little dietary selenium, the body uses stored selenium by converting the selenomethionine that is bound in different proteins.
SelenoPrecise contains both of these main selenium sources (selenomethionine and selenocysteine) plus several other selenium compounds.
The ability of selenium to bind to heavy metals
In the body, selenium binds to different heavy metals and forms insoluble compounds that are eventually discharged from the body. This process consumes some of the available selenium, leaving less for other important selenium-dependent processes*. Studies show that selenium binds mercury in a 1:1 ratio. When mercury and selenium bind, they form a chemically inert compound called mercury selenide, which is harmless to the body. However, the selenium that reacts with mercury is no longer available to selenoproteins that depend on the trace element. Insufficient selenoprotein synthesis can have a number of negative effects.
* Schrauzer GN Selenium and selenium-antagonistic elements in nutritional cancer prevention. Crit Rev Biotechnol. 2009;29(1):10-7.
What foods contain selenium?
Selenium is found in such things as fish, nuts, and whole-grain. People who do not consume these food items regularly may benefit from taking a selenium supplement to be on the safe side. The recommended daily allowance (RDA) for selenium is around 50-70 μg (it differs from country to country). Men generally need a little more selenium than women do.
Organically bound selenium has higher absorption
The selenium in the agricultural soil is inorganic. Once it gets absorbed by plants and ends up in animals who feed off the crops, it is converted into organic selenium. The selenium we get from our diet can be bound to amino acids such as methionine and cysteine. In contrast, selenium in supplements can either be organic or inorganic. It is known that organic selenium compounds are easier for the body to absorb and incorporate in the different selenium-dependent enzymes and selenoproteins.
The selenium content in agricultural soil differs
In countries where the agricultural soil is rich in selenium the population has a correspondingly high selenium intake. In the United States where there is a high selenium content in the soil (especially in the northern regions), the average selenium intake is around 60-220 μg daily.
As shown on the illustration, many European populations have low dietary selenium intake. The reason why the figures for Finland are not very low is that the country adds selenium to its agricultural fertilizers.
Selenium is many things
Selenium is a trace element and a mineral that is found in the soil in varying amounts. A country like the United States has a fairly high selenium content in the soil, while it is relatively low in most European countries. Grain and other plants absorb selenium from the soil. Therefore, the diet's selenium content depends on the amount of selenium in the agricultural soil.
Organic and inorganic selenium
It is important to pay attention to the different types of selenium when choosing supplements.
In selenium supplements, inorganic selenium is often used in the form of simple selenium salts such as sodium selenite or sodium selenate. Selenium is usually insoluble in water, but selenium in the form of selenite and selenate is water-soluble. A little over 50% of these two inorganic selenium salts is absorbed in the body (selenite has slightly better absorption than selenate). However, they are excreted relatively quickly which limits their usefulness.
Plants absorb inorganic selenium from the soil in the form of selenate. When the selenium is then incorporated into the plants as selenomethionine and, to a lesser extent, selenocysteine, it becomes organic selenium. The organic selenium compound L-selenomethionine - i.e., selenium attached to the amino acid methionine - can also be manufactured synthetically. Synthetic L-selenomethionine is widely used as an organic cell supplement and is one of the most thoroughly studied selenium compounds.
The selenium we get from animal food sources is primarily in the form of selenocysteine.
Selenium yeast originates from yeast cells that are grown in a selenium-containing nutrient substrate. It provides a high content of naturally occurring organic L-selenomethionine. The selenium yeast also contains methylselenocysteine as well as a variety of other organic selenium compounds that emulate the natural selenium variety that you get from a balanced diet. According to scientific studies, this broad scope of different selenium types is important. Before the selenium yeast is made into tablets it is inactivated by heat and turned into a powder, from which point it functions as a selenium- and protein-rich nutrient.
Selenium yeast differs in quality
There is also a difference between the quality of different yeast products. A non-standardized yeast is typically exposed to relatively large variations in the composition and amount of various selenium compounds. This also means that the absorbability of the selenium yeast can vary a lot. The yeast products with the best properties have pharmaceutical-grade quality with very tiny deviations in the composition and amount of different selenium compounds. Most importantly, these deviations are guaranteed to be within very narrow and predefined limits.
EU's Best-Documented Selenium Product
SelenoPrecise Eurotabs is one of the most well-substantiated selenium preparations when it comes to scientific documentation for stability, safety and absorption.
More than 40 scientific studies have been published having dealt with the quality, the stable selenium content, the high level of bio-availability, and the safety of SelenoPrecise. This is what makes the preparation an extremely well-documented selenium source. Also, it is the main reason why SelenoPrecise is used in scientific studies and research projects worldwide.
Many people take selenium supplements daily, but they are perhaps not aware of the large differences in quality and bioavailability in the different dietary supplements.
If you are not sure whether you are using the right product, you can try to test your current selenium tablet against SelenoPrecise - the best-documented selenium tablet.
Compare Your Current Selenium Product to SelenoPrecise®
Test Your Selenium Product
|Over 20 years of user experience in EU||Yes||?|
|Scientific evidence for bioavailability||Yes||?|
|Scientific data on safety||Yes||?|
|Scientific evidence of efficacy||Yes||?|
|Selected as European reference product for selenium-enriched yeast||Yes||?|
|Produced exclusively in Denmark under cGMP and under pharmaceutical control by the Danish authorities||Yes||?|
|Contains more than 20 organic selenium compounds, with the most dominant being L-selenomethionine||Yes||?|
|Bio-identical selenium compounds - i.e. the same types found in the selenium-containing foods||Yes||?|
|Tested and documented in 50 scientific studies||Yes||?|
|Patented product formulation||Yes||?|
|Used daily by thousands of consumers in more than 40 countries||Yes||?|
|Has a stable, uniform quality, which does not differ from production batch to the next||Yes||?|
|Is guaranteed to be manufactured under pharmaceutical control exclusively at our plant in Denmark in accordance with manufacturing regulations established by the Danish authorities||Yes||?|
SelenoPrecise - when you want to pay a little more for quality and safety.
1. Larsen EH, et al. Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemoprevention studies. J AOAC Int. 2004 Jan-Feb;87(1):225-32.
2. Rayman MP, et al. Effect of Supplementation With High-Selenium Yeast on Plasma Lipids. A Randomized Trial. Ann Intern Med. 2011.154(I0):656-665
3. Voĭtsekhovskaia IuG, et al. Assessment of some oxidative stress parameters in bronchial asthma patients beyond add-on selenium supplementation. Biomed Khim. 2007;53(5):577-84.
4. Bügel S, et al. Selenium from a high Se yeast supplement is well absorbed and retained in humans. Paper: 8th International Symposium on Metal Ions in Biology and Medecine, Metal Ions in Biology and Medicine, Budapest, 2004, 01.
5. Zachara BA, et al. Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase. Acta Biochim Pol. 2009;56(1):183-7.
The European Food Safety Authority (EFSA) has evaluated the evidence behind selenium and has acknowledged the following claims:
- Contributes to normal spermatogenesis
- Contributes to the maintenance of normal hair and nails
- Contributes to normal function of the immune system
- Contributes to normal thyroid function
- Contributes to the protection of cells from oxidative stress
Pharma Nord's patented selenium yeast approved in EU
Pharma Nordś selenium yeast SelenoPrecise is a highly bioavailable, standardized selenium yeast.
Read the safety assessment from EU's scientific experts EFSA of the source of selenium yeast used by Pharma Nord: Click here!