The original documented Q-Symbio Q10 - 100 mg
- Unique fomula with documented high bioavailability
- 20 years of consumer experience on safety and efficacy
- Documentation from more than 90 scientific studies
- Official reference product for ICQA(International Coenzyme Q10 Association)
- Bio-Quinon Active Q10 contains Q10 in vegetable oil in soft lightproof gelatin capsules
- Manufactured under Danish pharmaceutical control
- Q10 Quality
- What is Q10
- The product
Development and optimization for 25 years
Pharma Nord has spent more than 25 years developing and optimizing Bio-Quinon Q10 for the sole purpose of producing a Q10 preparation which scientifically can document it's superior bioavailability and quality. It is these targeted efforts that is the reason why Bio-Quinon Q10 today is the most sold Q10-brand in Europe and is also the Q10 preparation, that officially is used in international Q10 research represented by the International Coenzyme Q10 Association (ICQA).
Optimal oil formulation
A number of clinical studies have demonstrated that the Bio-Quinon composition with it's content of Q10 dissolved in vegetable oil and encapsulated in soft gelatin away from light, gives a higher bioavailability than any other composition formulations. (Ref. 1)
Bio-Quinon Q10's oil formulation provides higher bioavailability than other formulations
- Ref. 1. Weis M, et al. Bioavailability of Four Oral Coenzyme Q10 Formulations in Healthy Volunteers. Mol Aspect Med 199415s,273-80.
High bioavailability at body temperature
Q10 is a fat-soluble substance which is difficult for the body to absorb. However, thanks to a highly specialized manufacturing process where Q10 is dissolved in a vegetable oil solution and exposed to a patented heating process the Q10 crystals are able to dissolve entirely into single molecules at normal body temperature.
The fact that the Q10 crystals dissolve completely in this product due to its unique preheating process is the reason why Bio-Quinon Active Q10 can deliver such superior bioavailability of its active compound.
- Ref. 2. Singh RB, et al. Effects on absorption and oxidative stress of different oral Coenzyme Q10 dosages and intake strategy in healthy men. Biofactors 2005;25(1-4):219-24.
Dose and dosage
It is not only the formulation of the preparation that determines how much Q10 the body absorbs. It also depends on the dose and the dose intervals.
Data from a total of seven different human studies have shown that if you take two daily doses of Q10 at 100 mg each, you get a higher bioavailability than when you take a single dose of 200 mg.
Raw materials of the highest quality
Bio-Quinon Active Q10 contains 100% natural Q10. The raw material is produced by specialized yeast cells and is identical to the Q10 produced by the body. In contrast to bacteria-fermented Q10, this yeast-fermented Q10 does not contain any yeast components or impurities of unknown nature. The raw material is also completely free of the harmful cis-isomers, often found in cheap synthetic Q10 raw materials of low quality, which is normally produced from waste products from the tobacco industry.
All raw materials used in the Bio-Quinon Active Q10 undergo an extensive quality control before production of each batch.
All Pharma Nord's dietary supplements are not only produced according to GMP (Good Manufacturing Practice) and Critical Control Points (HACCP), but in fact according to the guidelines for production of medical drugs. The entire Pharma Nord production meet the strict quality rules that belong to these schemes.
Every step of the production process takes place under full quality control. Everything from mixing of raw materials and packing of the finished goods to transport of the products are continuously point-checked to ensure that there is complete control with the content of each capsule right until the moment when the customers holds the products in their hands.
A very safe substance
Coenzyme Q10 is a very safe substance. There has not been registered any serious unwanted effects from supplementation in controlled trials, even at doses of 1200 mg daily for one year (Ref.3). Also more than 20 years of research and consumer experience support the safety of Bio-Quinon Active Q10.
After discontinuation of supplementation the body's Q10 level will return to the same level as before the start of the supplementation study. This shows that Q10 supplementation does not affect the body's own ability to form the substance .
Pharma Nord has a complete security file on Bio-Quinon and more than 100 published scientific studies.
- Ref 3. Horstink MW, et al. The effect of coenzyme Q10 therapy in Parkinson disease could be symptomatic. Arch Neurol 2003;60(8):1170-72.
One of the best-documented Q10 products
Many people use coenzyme Q10 daily, but are perhaps not aware that there can be large differences in the products.
If you are in doubt whether you use the right product, you can try to test your current Q10 product against Bio-Quinon Q10, The world's most widespread Q10 brand:
|More than 20 years of consumer experience in EU||Yes||?|
|Scientific evidence for bioavailability||Yes||?|
|Scientific data on safety||Yes||?|
|Scientific evidence of effectiveness||Yes||?|
|Reference product in international research Q10||Yes||?|
|Produced in Denmark under GMP control after drug standardisation||Yes||?|
|Nature Identical Q10 - ie. Identical to the form the body uses||Yes||?|
|Tested and proven in more than 90 scientific studies||Yes||?|
|Documentation that the product does not affect the body's own production of Q10||Yes||?|
|Used daily by thousands of consumers in more than 40 countries||Yes||?|
|A unique matrix of oil and heating method ensures that the Q10-crystals are dissolved in the stomach and can be absorbed||Yes||?|
Bio-Quinon Active Q10 is EU's first product and contains easily absorbable Q10, which helps produce energy in body's cells and thus reduces fatigue and lassitude and contributes to healthy blood vessels.
Bio-Quinon Active Q10 - when you want to pay a little more for quality and safety.
- 1. Weis M, Mortensen SA, Rassing MR, Møller-Sonnergaard J et al.: Bioavailability of Four Oral Coenzyme Q10 Formulations in Healthy Volunteers; Mol Aspects Med 1994 15s, 273-280.
- 2. Singh RB; Niaz MA; Kumar A; Sindberg CD; Moesgaard S; Littarru GP:Eff ect on absorption and oxidative stress of diff erent oral Coenzyme Q10 dosages and intake strategy in healthy men.: Biofactors.: 25:1-4:219-24. (2005).
- 3. Horstink MW, van Engelen BG: The eff ect of coenzyme Q10 therapy in Parkinson disease could be symptomatic.; Arch Neurol 2003 60, no. 8, 1170-72
- 4. Langsjoen P, et al. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
- Mortensen SA. Perspectives on therapy of cardiovascular diseases with coenzyme Q10 (ubiquinone). Clin Investig. 1993;71(8 Suppl):S116-23.
Coenzyme Q10 (or just Q10) is a vitamin-like substance. It's also called ubiquinone (ubi is Latin and means ”everywhere”). When a cell needs energy it convert fat, carbohydrate, protein, and alcohol into ATP (adenosine triphosphate), a molecule that stores energy in its chemical form. The cell breaks down the ATP molecule and releases the energy trapped inside. The entire process takes place inside the cells in some small bean-shaped structures called mitochondria. Coenzyme Q10 is found in all mitochondria. Muscle cells are particularly dependent on large amounts of energy, which is why muscle cells contain substantially more mitochondria than other types of cells. The heart muscle is a good example of body tissue with cells that contain a large number of mitochondria and have a correspondingly large energy requirement.
Raw material Q10 is a fat-soluble, crystalline substance with a very low absorbtion, but using a special manufacturing technique in which Q10 undergoes a special heat treatment the Q10 crystals dissolve completely at body temperature. It is this complete solution of Q10, a high quality raw material and manufacturing according to the farmaceutical and the GMP protocol, which is the reason that Bio-Quinon Active Q10 Gold has achieved such good bioavailability of the active substance.
Sources of Q10
We get relative small amounts of Q10 from several types of food, some of the best sources of Q10 in food are:
- organ meat
- soy oil
In addition, humans are able to synthesize Q10 in the body. The process, which takes place in the body's cells, slows down as we grow older and as a result of disease. According to experts, the body’s Q10 levels peak at the age of 20-25 years from which point it begins on a downward slope.
Science has not been able to quantify exactly how much Q10 is provided by means of the diet but it is estimated to be somewhere around 5-10 mg daily. The body has a Q10 reserve that amounts to about 1 – 1.5 grams. The highest concentrations are found in the heart, liver, and kidneys.
Big difference in Q10 products
Pharma Nord has spent more than 20 years documenting the absorbability, effectiveness, and safety of the product Bio-Quinone Q10. But many Q10 products are currently sold without any documentation which may give the user assurance of an effect. In the wake of this a number of claims has emerged about what kind of Q10 is best. A team of U.S. Researchers has reviewed and weeded out the false claims. What remains are the facts about the effect and use of Q10.
Unprocessed Q10 is poorly absorbed
Optimum absorbability has been the keyword in the development of Bio-Quinone Q10, and this is documented in approx. 40 scientific studies.
One of the biggest challenges associated with Q10 as a supplement is that the substance generally is not readily absorbed by the body. Q10 in other words, has a low bioavailability. The Q10 molecule is a relatively large molecule and this is the main reason for its poor absorbtion in the body and as a result of its molecular structure, it is fat soluble.
Slowly release into the blood
Q10 is absorbed in the intestinal wall along with fat and is then transported by the lymph vessels to the subclavian vein, where it emptied into the venous blood. This slow mode of transport results in a maximum concentration of Q10 in the blood 6-8 hours after ingestion. Therefore, it is preferable to take Q10 with breakfast or perhaps lunch. If you take more than 1 capsule daily, the effect is larger by spreading the dose throughout the day - eg. one capsule at breakfast and one capsule at lunch time - rather than taking the daily dosage at once.
Crystals are not absorbed
A Bio-Quinone Q10 capsule contains a special oil matrix in which the substance Q10 is in a molecular form. The starting point for all products is the Q10 raw material consisting of crystals, which in practice are not absorbed by the body. Q10 must be dissolved into single Q10 molecules before they can be absorbed. Less than 1% of Q10 is absorbed from products solely consisting of crystalline Q10, typically tablet products and hard capsules using unprocessed Q10 crystals. The crystals may be dissolved by using a special oil mixture, and a subsequent heating method, thereby, releasing Q10 into single molecules, which provides a quick and good absorption with oil.
Q10 always fat-soluble
A marketing strategy has gone on to claim that it is better to make Q10 water soluble, but neither a change to the Q10 molecule or placement of the fat-soluble Q10 molecules in liposomes (small spheres with an outer fatty membrane and an inner aqueous membrane) or linking Q10 to micelles (small spheres with a fatty core and a water-loving surface) or attaching nano-particles to Q10 will make the Q10 molecule more water soluble.
If you try, you just end up with an even bigger Q10 molecule complex, but no increased bioavailability and the Q10 molecule will still predominantly be fat soluble. If you choose to go the opposite way and make the molecule smaller, this will surely make the molecule more water soluble and more absorbable, but such a reduced molecule will no longer be Q10, but would be reduced to Q9 or Q8 which is of no value to humans.
Most documentation on ubiquinone
Q10 is found in two forms. An oxidized form called ubiquinone as well as a reduced form called ubiquinol. Ubiquinol is also marketed as active Q10 although ubiquinol isn't more active than ubiquinone. The form of Q10 we produce in our cells, is the oxidized ubiquinone. Also Q10 from our food is predominantly the oxidized form. When we absorb the oxidized ubiquinone from the intestine it is automatically converted to reduced ubiquinol. In the blood and lymphatic system 90-95% of Q10 is in the form of ubiquinol. In the cells' energy-producing mitochondria Q10 alternate continuously between these two forms, a feature that is crucial for Q10s effects in the body.
Therefore, it is of minor importance what form of Q10 you consume, your body will still convert the oxidized ubiquinone to reduced ubiquinol. To date, almost all documentation on efficacy and safety are done with the oxidized form, ubiquinone.
- Ubiquinone = oxidized Q10
- Ubiquinol = reduced Q10
Pharma Nord Q10 used in the Q-symbio study
One of the latest studies done with Pharma Nord's Q10 was the Q-Symbio study. Professor Sven Aage Mortensen from Rigshospitalet in Copenhagen and his colleagues in EU and Asia presented the results of the Q-symbio study for the first time at a congress of cardiologists in Lisbon, Portugal, 23 - 28 May 2013.
420 patients from nine different countries was included in the Q-symbio study who examined a group of persons with low levels of Q10.
The active treatment consisted of a soft gelatin capsule with 100 mg of Q10 three times a day for two years. The study wanted to show how well those who got Q10 performed compared to those who had to do without.
Last year we saw another study with healthy elderly in the so-called KiSel-10 study where Dr. Urban Alehagen and his team used the same Pharma Nord Q10 with the selenium product SelenoPrecise – and with similar results.
Why Q10 from Pharma Nord?
Researchers prefer Pharma Nord Q10 because it has documentation from more than 90 scientific studies and also documentation for high bioavailability and safety. It is manufactured under Danish pharmaceutical control and is the official reference product for ICQA (International Coenzyme Q10 Association).
Pharma Nord has also Q10 registered as a drug.
All Pharma Nord's products are based on thorough scientific research. Pharma Nord's own research department is continuously working to be fully abreast of the latest knowledge about health and nutrition. This requires a careful monitoring of the research progress and also planning and conduct of investigations of Pharma Nord's products in cooperation with the leading Q10 experts in the world.
|1 - Is Q10 on the doping list?|
Furthermore, as part of the safety documentation for our Q10 preparation, Pharma Nord has had its Q10 tested by the Hungarian Doping Institute for possible doping-like effects and can provide a certificate attesting to its Q10’s lack of doping properties. This certificate is intended mostly for athletes who need to know exactly what they are consuming.
|2 - What kind of Q10 is best absorbed?|
Various Q10 products are available either as tablets or as capsules. The Q10 content may be in the form of crystals or granules, encapsulated in liposomes, in micelles attached to nanoparticles or dissolved in oil.
The size alone of the Q10 molecule - it has a considerable size, approx. 5.5 nm long and 864 times heavier than a hydrogen atom - means that Q10 is basically not an easily absorbed substance. The Q10 raw material is an orange brown crystalline powder, and these Q10-crystals cannot be absorbed directly into the body. The absorption of unprocessed Q10 powder is less than 1%. In addition, Q10 is a fat-soluble substance that has to be absorbed in the small intestine along with fat. It is possible to attach other substances to the Q10 molecule that will make it somewhat more water-soluble, but doing so will make the big Q10 molecule even bigger, whereby the advantage disappears, and the Q10 complex will still largely be fat-soluble. It sounds impressive to state that a Q10 product is three times more absorbable than a competing product, but if the competing product simply consists of Q10 crystals with a less than 1% absorption rate, the claim is not particularly impressive. Producers of Q10 supplements have to treat the Q10 raw material in a special way in order to achieve an effective absorption. The most bioavailable Q10 products are dissolved in a vegetable oil in which the crystals must be dissolved completely.
|3 - Why can't I feel the effect of Q10?|
Many so-called energy-based products get their effect from caffeine and caffeine-like substances from various plants that stimulate the adrenal glands to secrete stress hormones. Coenzyme 10, on the other hand, is present in all body cells and is part of the cells’ natural way of producing energy. Thus, the biochemical processes in the body and the experience are not the same for these two different types of products. The fact that you may not feel an immediate effect of Q10 may also be due to one or more of the following factors:
|4 - How do I Make the Most of my Q10 Product?|
The trace element selenium is part of the seleno protein thioredoxin reductase, which helps in reducing ubiquinone to ubiqionol in the body.
Furthermore, you can take a supplement of the amino acid carnitine, which interacts closely with Q10 in the cells' mitochondria. Carnitine helps with the transport of fatty acids into the mitochondria, and Q10 is involved in the oxidation process that converts these fatty acids into energy in the form of ATP.
|5 - How do I optimize the body's own production of Q10?|
|6 - What are the best dietary sources of Q10?|
|7 - Are there adverse effects from Q10?|
|8 - How long can I take Q10?|
|9 - What is the difference between oxidized Q10 (ubiquinone) and reduced Q10 (ubiquinol)?|
At the molecular level, the difference between ubiquinone (oxidized Q10) and ubiquinol (reduced Q10) is not big. Ubiquinol has two extra hydrogen molecules and forms, in conjunction with oxygen, a so-called hydroxyl group on the head of the Q10 molecule, which is a quinone ring.
The two forms of Q10, however, have quite different roles in the body. Ubiquinol donates electrons, whereas ubiquinone receives electrons. Ubiquinol performs an important function as an antioxidant in the body, but in the cells' energy producing mitochondria, the two forms constantly switch from the one form to the other - that is, from the oxidized to the reduced form and back again. Thus, one cannot say that one form of Q10 is more active or more important than the other.
The two forms of Q10 also have different colors. Normal Q10 is a clear orange, yellowish substance, whereas reduced Q10, which is oxidatively unstable, has a milky-white color. It is therefore easy to test whether the product you buy is normal or reduced Q10. The Q10 that we produce in the body's cells is oxidized Q10, whereas 90-95% of Q10 circulating in the blood is in the form of reduced Q10.
Q10 from the diet consists of both ubiquinone and ubiquinol, about half of each7. Both forms are absorbed in the intestine along with fat. Q10 is slowly transported from the lymph into the blood. Already during the passage through the intestinal wall into the lymph, the absorbed ubiquinone is being converted into reduced ubiquinol. Consequently, there is no good reason to choose a product containing ubiquinol, as your body is able to absorb and convert ubiquinone from the gut to ubiquinol. The body is naturally able to reduce ubiquinone Q10 by itself.
Q10 product's ability to be absorbed from the intestine is one of its most important aspects. Ubiquinone of good quality has been found to be absorbed just as effectively as ubiquinol. A few unsubstantiated reports suggest, however, that products with ubiquinol may be relevant to a very small percentage of people who have impaired uptake of Q10 from the gut.
Finally, ubiquinol preparations are usually more expensive to buy than ubiquinone preparations.
|10 - Does cholesterol lowering drugs reduce the body's level of Q10?|
There are different types of statins working in different ways, and they are not equally strong. The most common complaint about the adverse effects of statins is muscle pain. The pain occurs when the muscles have to work with too little energy. However, not everybody experiences adverse effects from statins.
The effect differs from individual to individual depending on how much Q10 is required to normalize the body's Q10 level during statin treatment. You must monitor your own body’s needs.
|11 - How much Q10 do we need?|
|12 - How long does it take for Q10 to work?|
In practical terms, this means that it is advisable to start with a slightly higher daily dose and then reduce the dose after some time if necessary. Take Q10 for at least a month, but do not expect maximum absorption in the tissue until after at least six months of use.
|13 - What is the source of Pharma Nord's Q10?|
|14 - Do I risk infection from Mad Cow Disease from the Softgel Capsules?|
|15 - Are there any health risk using the dye ammonia caramel in Bio-Quinone GOLD capsules?|
Pharma Nord is using this dye in Bio-quinone GOLD as part of our quality assurance to ensure capsule quality and also to ensure that the ingredients are unimpaired right up to the product's expiry date. Another purpose has been to protect the ingredients against degradation from light. We want to produce all our products using the most environmentally friendly components. At the same time, we need those excipients that best ensures the quality of our products.
Caramel coloring including E150 C is among the oldest and most widely used dyes. They are found in almost any industrially produced food. Ammonia caramel is a substance approved for use in food, up to a limit of 200 mg / kg body weight per day, equivalent to 12000 mg for a person weighing 60 kg. In comparison, one capsule Bio-quinone Gold contains approximately 25 mg, a negligible amount compared to all the other sources of ammonia caramel we encounter in everyday life.
|16 - How can I avoid eating the gelatin in the Q10 capsules?|
|17 - Is the gelatin in your Q10 capsules Halal certified?|
|18 - What is the reason for using palm oil in your Q10 products?|
Some people are against the use of palm oil in foods for various reasons. Some consider palm oil to be of such poor quality that it has adverse health effects. In addition, there is the environmental aspects, where palm oil production contributes to cutting down rain forrest.
All this has nothing to do with Pharma Nord's palm oil. Originally we used soybean oil, but in 2009 we shifted to the use of palm oil in some Q10 products. This was done for the following reasons:
Because of the way soybeans are grown, it is almost impossible to guarantee that a given soybean crop is 100% free of GMOs. Palm oil is guaranteed GMO free.
Numerous scientific studies have confirmed that palm oil has a better health profile than many other partially hydrogenated (hardened) vegetable oils normally used in food production.
The palm oil is not hydrogenated (hardened). Due to its natural balance of saturated and unsaturated fatty acids, palm oil requires no hydrogenation.
The palm oil we use is a pharmaceutical grade quality. It has no negative effect on cholesterol and other health risk factors. Extensive scientific data, including a number of human studies suggest that supply of palm oil and its liquid fractions (palm olein, super olein) fed regularly from the diet does not result in an increase in the total amount of cholesterol in the blood. In fact, palm oil has significant health benefits, especially compared to many of the partially hydrogenated oils used in modern food production.
Ref: The United Nations University Press, Food and Nutrition Bulletin, vol. 15 (1993/1994), Number 2, june 1994
EU regulation limits the content of trans fatty acids in foods. Palm oil has a high content of mono-unsaturated fatty acids and contains no trans-fatty acids.
By switching to palm oil Pharma Nord is able to use an oil that has been certified by WWF as environmentally sustainable.
Certified, environmentally sustainable plantation management
|19 - Can the Q10 capsule's shelf life be extended by storage in the refrigerator?|
|1 capsule contains||%RDA*|
|Coenzyme Q10 (ubiquinone)||100 mg|
|Dissolved in vegetable oil in soft gelatin capsules.|
|Vitamin C||25 mg||31%|
*Recommended Daily Allowance.
1 capsule daily, unless otherwise advised.
Do not exceed the recommended daily dosage.
Do not chew the capsules, but swallow them whole, preferably during/after a meal.
Dietary supplements are no substitute for a varied diet.
A healthy lifestyle and a varied balanced diet are important for maintaining good health.
Palm oil*, capsule shell: gelatin, glycerol, coenzyme Q10 (ubiquinone), humectant: glycerol, vitamin: L-ascorbic acid, color: ammonia caramel, humectant: purified water, thickening agant: silica, color: titanium dioxide.
Dark, dry and at room temperature.
Keep out of reach of young children.
*From sustainable farming.
What is Bio-Quinon Active Q10 Gold?
Bio-Quinon Active Q10 Gold consists of soft gelatin capsules with 100 mg of Q10 in the form of active ubiquinone dissolved in vegetable oil. The capsules contains vitamin C, which contributes to normal energy metabolism.
Q10 is to some extent sensitive to sunlight and oxygen. The oil used in the Bio-Quinon Active Q10, is purged of oxygen by means of a special technique. Furthermore, the capsules are effectively protected from light to prevent the active ingredients in the capsules from being damaged or destroyed.
The preparation has for several decades been one of the world’s most widely sold Q10 brands, due to the fact that it is able to demonstrate and document a high absorption.
- Bio-Quinon Active Q10 contains Q10 in vegetable oil in soft, light-protected gelatin capsules
- This formula has been able to document extreme high bioavailability
- Bio-Quinon Active Q10 is the official reference preparation of ICQA (International Coenzyme
- Q10 Association)
- The Q10 raw material in Bio-Quinon Active Q10 is identical with the type of Q10 that is
- made in the human body (nature identical)
- The Q10 form used in Bio-Quinon Active Q10 is the natural all-trans form, which is devoid of synthetic cis-isomers.
- Unique mixture of vegetable oils (from certified sustainable farming) in gelatin capsules
- Bio-Quinon Active Q10 is documented in over 90 published studies
- Added vitamin C which contribute to the formation of energy in body cells and to healthy blood vessels
- Comes in pharmaceutical quality
What is Vitamin C?
Vitamin C is also called ascorbic acid. It is a water-soluble vitamin with many functions in the body. Among other things, it acts as co-factor in a number of enzymatic processes. Vitamin C protects the body's cells against oxidative stress, it contributes to our normal energy metabolism and helps to reduce fatigue and exhaustion.
The EU Food Safety Agency (EFSA) has evaluated the evidence behind the product's content of vitamin C and has acknowledged the following statements:
- Contributes to the reduction of tiredness and fatigue
- Contributes to normal collagen formation for the normal function of the blood vessels
- Contributes to normal collagen formation for the normal function of gums and teeth
- Contributes to normal energy-yielding metabolism
Bio-Carnitine as carnitine is involved in transport and oxidation of fatty acids into the mitochondria where Q10 contributes to their metabolism.
SelenoPrecise as selenium is integrated in selenoproteins involved in keeping Q10 in its reduced form in the body.
Zymbion Q10 Toothpaste increases the amount of coenzyme Q10 in the gingival pockets. This external supply is complemented by internal Q10 from Bio-Quinon Active Q10.